NLRP6 inflammasome orchestrates the colonic host-microbial interface by regulating goblet cell mucus secretion.

ABSTRACT: Mucus production by goblet cells of the large intestine serves as a crucial antimicrobial protective mechanism at the interface between the eukaryotic and prokaryotic cells of the mammalian intestinal ecosystem. However, the regulatory pathways involved in goblet cell-induced mucus secretion remain largely unknown. Here, we demonstrate that the NLRP6 inflammasome, a recently described regulator of colonic microbiota composition and biogeographical distribution, is a critical orchestrator of goblet cell mucin granule exocytosis. NLRP6 deficiency leads to defective autophagy in goblet cells and abrogated mucus secretion into the large intestinal lumen. Consequently, NLRP6 inflammasome-deficient mice are unable to clear enteric pathogens from the mucosal surface, rendering them highly suscept

SUBMITTER: Wlodarska M 

PROVIDER: S-EPMC4017640 | biostudies-literature | 2014 Feb

REPOSITORIES: biostudies-literature