Ontology highlight
ABSTRACT:
SUBMITTER: Schumpert B
PROVIDER: S-EPMC4017863 | biostudies-literature | 2013 Apr-May
REPOSITORIES: biostudies-literature
Mechanisms of development 20130108 4-5
Is focal adhesion kinase (FAK) needed for embryonic cleavage? We find that FAK is expressed during early cleavage divisions of sea urchin embryos as determined by polyclonal antibodies to the Lytechinus variegatus protein. FAK is absent in eggs and zygotes and then cycles in abundance during the first cleavages after fertilization. It is maximal at anaphase, similar to the destruction and synthesis of cyclin proteins. To investigate whether FAK is needed during early cleavage, we interfered with ...[more]