Cost-effectiveness of competing strategies for management of recurrent Clostridium difficile infection: a decision analysis.

ABSTRACT:

Background

Clostridium difficile infection (CDI) is an important cause of morbidity and healthcare costs, and is characterized by high rates of disease recurrence. The cost-effectiveness of newer treatments for recurrent CDI has not been examined, yet would be important to inform clinical practice. The aim of this study was to analyze the cost effectiveness of competing strategies for recurrent CDI.

Methods

We constructed a decision-analytic model comparing 4 treatment strategies for first-line treatment of recurrent CDI in a population with a median age of 65 years: metronidazole, vancomycin, fidaxomicin, and fecal microbiota transplant (FMT). We modeled up to 2 additional recurrences following the initial recurrence. We assumed FMT delivery via colonoscopy as our base case

SUBMITTER: Konijeti GG 

PROVIDER: S-EPMC4017891 | biostudies-literature | 2014 Jun

REPOSITORIES: biostudies-literature