Evoked and spontaneous transmission favored by distinct sets of synapses.

ABSTRACT:

Background

Spontaneous "miniature" transmitter release takes place at low rates at all synapses. Long thought of as an unavoidable leak, spontaneous release has recently been suggested to be mediated by distinct pre- and postsynaptic molecular machineries and to have a specialized role in setting up and adjusting neuronal circuits. It remains unclear how spontaneous and evoked transmission are related at individual synapses, how they are distributed spatially when an axon makes multiple contacts with a target, and whether they are commonly regulated.

Results

Electrophysiological recordings in the Drosophila larval neuromuscular junction, in the presence of the use-dependent glutamate receptor (GluR) blocker philanthotoxin, indicated that spontaneous and evoked transmission e

SUBMITTER: Peled ES 

PROVIDER: S-EPMC4017949 | biostudies-literature | 2014 Mar

REPOSITORIES: biostudies-literature