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Structure-function studies of DNA polymerase λ.

ABSTRACT: DNA polymerase λ (pol λ) functions in DNA repair with its main roles considered to be filling short gaps during repair of double-strand breaks by nonhomologous end joining and during base excision repair. As indicated by structural and biochemical studies over the past 10 years, pol λ shares many common properties with other family X siblings (pol β, pol μ, and terminal deoxynucleotidyl transferase) but also has unique structural features that determine its specific functions. In this review, we consider how structural studies over the past decade furthered our understanding of the behavior and biological roles of pol λ.

SUBMITTER: Bebenek K

PROVIDER: S-EPMC4018081 | biostudies-literature | 2014 May

REPOSITORIES: biostudies-literature

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Structure-function studies of DNA polymerase λ.

Bebenek Katarzyna K Pedersen Lars C LC Kunkel Thomas A TA

Biochemistry 20140423 17

DNA polymerase λ (pol λ) functions in DNA repair with its main roles considered to be filling short gaps during repair of double-strand breaks by nonhomologous end joining and during base excision repair. As indicated by structural and biochemical studies over the past 10 years, pol λ shares many common properties with other family X siblings (pol β, pol μ, and terminal deoxynucleotidyl transferase) but also has unique structural features that determine its specific functions. In this review, we ...[more]

PMID: 24716527

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