Discovery of novel cyanamide-based inhibitors of cathepsin C.

ABSTRACT: The discovery of potent and selective cyanamide-based inhibitors of the cysteine protease cathepsin C is detailed. Optimization of the template with regard to plasma stability led to the identification of compound 17, a potent cathepsin C inhibitor with excellent selectivity over other cathepsins and potent in vivo activity in a cigarette smoke mouse model.

SUBMITTER: Laine D 

PROVIDER: S-EPMC4018094 | biostudies-literature | 2011 Feb

REPOSITORIES: biostudies-literature