Structure guided development of potent reversibly binding penicillin binding protein inhibitors.

ABSTRACT: Following from the evaluation of different types of electrophiles, combined modeling and crystallographic analyses are used to generate potent boronic acid based inhibitors of a penicillin binding protein. The results suggest that a structurally informed approach to penicillin binding protein inhibition will be useful for the development of both improved reversibly binding inhibitors, including boronic acids, and acylating inhibitors, such as β-lactams.

SUBMITTER: Woon EC 

PROVIDER: S-EPMC4018096 | biostudies-literature | 2011 Mar

REPOSITORIES: biostudies-literature