Common variants near melanocortin 4 receptor are associated with general and visceral adiposity in European- and African-American youth.

ABSTRACT:

Objective

Recent genome-wide association studies found common variants near the melanocortin 4 receptor gene associated with obesity. This study aimed to assess the influence of the identified single nucleotide polymorphisms rs17782313 and rs17700633 on general and visceral adiposity in European- and African-American youth.

Study design

In 1890 youth (49.1% European-American, 45.6% male, mean age 16.7 years), we examined the associations of the rs17782313 and rs17700633 with anthropometry, percent body fat, visceral adipose tissue, and subcutaneous abdominal adipose tissue. Interaction of the single nucleotide polymorphisms with ethnicity or sex was investigated and haplotype analyses conducted.

Results

Rs17782313 was significantly associated with weight (P = .02) and

SUBMITTER: Liu G 

PROVIDER: S-EPMC4018229 | biostudies-literature | 2010 Apr

REPOSITORIES: biostudies-literature