Attention, impulsivity, and cognitive flexibility in adult male rats exposed to ethanol binge during adolescence as measured in the five-choice serial reaction time task: the effects of task and ethanol challenges.

ABSTRACT:

Rationale

Alcohol abuse is prevalent in adolescent humans, but the long-term behavioral consequences of binge alcohol drinking are unknown.

Objectives

This study investigated the long-term effects of adolescent intermittent ethanol (AIE) exposure on attention and impulsivity.

Methods

Adolescent male rats were exposed to 5 g/kg of 25% (v/w) ethanol every 8 h for 4 days. During adulthood, rats were tested in the five-choice serial reaction time task (5-CSRTT) assessing attention, impulsivity and cognitive flexibility.

Results

There was no metabolic tolerance to ethanol in adolescent rats during AIE exposure. In the 5-CSRTT under baseline conditions, there were no differences between AIE-exposed and control rats in accuracy, omissions, or premature responses, alth

SUBMITTER: Semenova S 

PROVIDER: S-EPMC4018242 | biostudies-literature | 2012 Jan

REPOSITORIES: biostudies-literature