MiR-422a as a potential cellular microRNA biomarker for postmenopausal osteoporosis.

ABSTRACT:

Background

MicroRNAs (miRNAs) are a class of short non-coding RNA molecules that regulate gene expression by targeting mRNAs. Recently, miRNAs have been shown to play important roles in the etiology of various diseases. However, little is known about their roles in the development of osteoporosis. Circulating monocytes are osteoclast precursors that also produce various factors important for osteoclastogenesis. Previously, we have identified a potential biomarker miR-133a in circulating monocytes for postmenopausal osteoporosis. In this study, we aimed to further identify significant miRNA biomarkers in human circulating monocytes underlying postmenopausal osteoporosis.

Methodology/principal findings

We used ABI TaqMan miRNA array followed by qRT-PCR validation in human circ

SUBMITTER: Cao Z 

PROVIDER: S-EPMC4018259 | biostudies-literature | 2014

REPOSITORIES: biostudies-literature