Clinical features of methamphetamine-induced paranoia and preliminary genetic association with DBH-1021C→T in a Thai treatment cohort.

ABSTRACT:

Aims

To explore the clinical features of methamphetamine-induced paranoia (MIP) and associations between MIP and a genetic polymorphism in dopamine β-hydroxylase (DBH-1021C→T).

Design

Retrospective analysis of clinical presentation and genetic association by χ(2) test and logistic regression analysis.

Setting

A Thai substance abuse treatment center.

Participants

A total of 727 methamphetamine-dependent (MD) individuals.

Measurements

Clinical: Semi-Structured Assessment for Drug Dependence and Alcoholism (SSADDA) and the Methamphetamine Experience Questionnaire (MEQ). Genetic: DBH-1021C→T.

Findings

Forty per cent of individuals (289 of 727; 39.8%) with MD had MIP. Within-binge latency to MIP onset occurred more rapidly in the most recent compared w

SUBMITTER: Kalayasiri R 

PROVIDER: S-EPMC4018411 | biostudies-literature | 2014 Jun

REPOSITORIES: biostudies-literature