GPR120 (FFAR4) is preferentially expressed in pancreatic delta cells and regulates somatostatin secretion from murine islets of Langerhans.

ABSTRACT:

Aims/hypothesis

The NEFA-responsive G-protein coupled receptor 120 (GPR120) has been implicated in the regulation of inflammation, in the control of incretin secretion and as a predisposing factor influencing the development of type 2 diabetes by regulation of islet cell apoptosis. However, there is still considerable controversy about the tissue distribution of GPR120 and, in particular, it remains unclear which islet cell types express this molecule. In the present study, we have addressed this issue by constructing a Gpr120-knockout/β-galactosidase (LacZ) knock-in (KO/KI) mouse to examine the distribution and functional role of GPR120 in the endocrine pancreas.

Methods

A KO/KI mouse was generated in which exon 1 of the Gpr120 gene (also known as Ffar4) was replaced in fra

SUBMITTER: Stone VM 

PROVIDER: S-EPMC4018485 | biostudies-literature | 2014 Jun

REPOSITORIES: biostudies-literature