Ontology highlight
ABSTRACT:
SUBMITTER: Chapuy B
PROVIDER: S-EPMC4018722 | biostudies-literature | 2013 Dec
REPOSITORIES: biostudies-literature
Cancer cell 20131201 6
Diffuse large B cell lymphoma (DLBCL) is a biologically heterogeneous and clinically aggressive disease. Here, we explore the role of bromodomain and extra-terminal domain (BET) proteins in DLBCL, using integrative chemical genetics and functional epigenomics. We observe highly asymmetric loading of bromodomain 4 (BRD4) at enhancers, with approximately 33% of all BRD4 localizing to enhancers at 1.6% of occupied genes. These super-enhancers prove particularly sensitive to bromodomain inhibition, ...[more]