Meta-analysis of oxidative stress in schizophrenia.

ABSTRACT:

Background

Schizophrenia is associated with impaired antioxidant defense, including abnormal serum, plasma, and red blood cell (RBC) oxidative stress parameters. We performed a meta-analysis of these associations, considering the effect of clinical status and antipsychotic treatment after an acute exacerbation of psychosis.

Methods

We identified articles by searching PubMed, PsychInfo, and Institute for Scientific Information, and the reference lists of identified studies.

Results

Forty-four studies met the inclusion criteria. Total antioxidant status seemed to be a state marker, because levels were significantly decreased in cross-sectional studies of serum and plasma in first-episode psychosis (FEP) and significantly increased in longitudinal studies of antipsychoti

SUBMITTER: Flatow J 

PROVIDER: S-EPMC4018767 | biostudies-literature | 2013 Sep

REPOSITORIES: biostudies-literature