Chimeric plantibody passively protects mice against aerosolized ricin challenge.

ABSTRACT: Recent incidents in the United States and abroad have heightened concerns about the use of ricin toxin as a bioterrorism agent. In this study, we produced, using a robust plant-based platform, four chimeric toxin-neutralizing monoclonal antibodies that were then evaluated for the ability to passively protect mice from a lethal-dose ricin challenge. The most effective antibody, c-PB10, was further evaluated in mice as a therapeutic following ricin exposure by injection and inhalation.

SUBMITTER: Sully EK 

PROVIDER: S-EPMC4018890 | biostudies-literature | 2014 May

REPOSITORIES: biostudies-literature