Autism spectrum disorder: interaction of air pollution with the MET receptor tyrosine kinase gene.

ABSTRACT:

Background

Independent studies report association of autism spectrum disorder with air pollution exposure and a functional promoter variant (rs1858830) in the MET receptor tyrosine kinase (MET) gene. Toxicological data find altered brain Met expression in mice after prenatal exposure to a model air pollutant. Our objective was to investigate whether air pollution exposure and MET rs1858830 genotype interact to alter the risk of autism spectrum disorder.

Methods

We studied 252 cases of autism spectrum disorder and 156 typically developing controls from the Childhood Autism Risk from Genetics and the Environment Study. Air pollution exposure was assigned for local traffic-related sources and regional sources (particulate matter, nitrogen dioxide, and ozone). MET genotype was d

SUBMITTER: Volk HE 

PROVIDER: S-EPMC4019012 | biostudies-literature | 2014 Jan

REPOSITORIES: biostudies-literature