Anti-lyssaviral activity of interferons κ and ω from the serotine bat, Eptesicus serotinus.

ABSTRACT:

Unlabelled

Interferons (IFNs) are cytokines produced by host cells in response to the infection with pathogens. By binding to the corresponding receptors, IFNs trigger different pathways to block intracellular replication and growth of pathogens and to impede the infection of surrounding cells. Due to their key role in host defense against viral infections, as well as for clinical therapies, the IFN responses and regulation mechanisms are well studied. However, studies of type I IFNs have mainly focused on alpha interferon (IFN-α) and IFN-β subtypes. Knowledge of IFN-κ and IFN-ω is limited. Moreover, most studies are performed in humans or mouse models but not in the original host of zoonotic pathogens. Bats are important reservoirs and transmitters of zoonotic viruses such as lyss

SUBMITTER: He X 

PROVIDER: S-EPMC4019090 | biostudies-literature | 2014 May

REPOSITORIES: biostudies-literature