Adjunctive management of central line-associated bloodstream infections with 70% ethanol-lock therapy.

ABSTRACT:

Objectives

Ethanol is bactericidal against most pathogens implicated in central line-associated bloodstream infections (CLABSIs) and biofilms. Current Infectious Diseases Society of America guidelines cite insufficient evidence to support adjunctive ethanol-lock therapy (ELT) for central venous catheter (CVC) salvage in patients with CLABSI in combination with systemic antimicrobial treatment. We evaluated the safety and potential efficacy of 70% ELT for CLABSI at our institution after implementation of a hospital ELT protocol.

Methods

We collected data on all patients treated with adjunctive 70% ELT for catheter salvage from September 2009 to September 2011 and assessed clinical outcomes and adverse events associated with ELT.

Results

Sixty-eight hospitalized patient

SUBMITTER: Kubiak DW 

PROVIDER: S-EPMC4019330 | biostudies-literature | 2014 Jun

REPOSITORIES: biostudies-literature