Prefrontal cortical deficits and impaired cognition-emotion interactions in schizophrenia.

ABSTRACT:

Objective

Despite schizophrenia patients' reports of diminished experience of emotion in interviews and self-report measures, their emotional experience in the presence of emotional stimuli and in daily life ("in the moment") appears largely intact. To examine emotion-cognition interactions, the authors tested the hypothesis that schizophrenia patients have unimpaired in-the-moment emotional reactivity but have a deficit in prefrontal cortical mechanisms needed to maintain and report on experience following exposure to emotional stimuli.

Method

Using a slow event-related functional MRI paradigm, the authors examined the brain activity of 23 schizophrenia patients and 24 healthy comparison subjects during trials in which they viewed an affective picture and, after a delay, re

SUBMITTER: Ursu S 

PROVIDER: S-EPMC4019338 | biostudies-literature | 2011 Mar

REPOSITORIES: biostudies-literature