Dlx6 regulates molecular properties of the striatum and central nucleus of the amygdala.

ABSTRACT: We describe here the prenatal telencephalic expression of Dlx6 RNA and β-galactosidase driven from a mutant Dlx6 locus. The mutant Dlx6 allele, which we believe is either a null or severe hypomorph, has an IRES-lacZ-neomycin resistance cassette inserted into the Dlx6 homeobox coding sequence (Dlx6(LacZ) ). We compared expression from the Dlx6-lacZ (Dlx6(LacZ) ) allele in heterozygotes (Dlx6(LacZ/+) ), with the expression of Dlx1, Dlx2, Dlx5 and Dlx6 RNA. Like these wild-type alleles, Dlx6(LacZ) is expressed in the developing ganglionic eminences, and their derivatives. Unlike the other Dlx genes, Dlx6 and Dlx6(LacZ) expression is not readily observed in tangentially migrating interneurons. In addition to Dlx6's expression at later stages of differentiation of many basal ganglia nuclei, it

SUBMITTER: Wang B 

PROVIDER: S-EPMC4019376 | biostudies-literature | 2011 Aug

REPOSITORIES: biostudies-literature