Next-generation sequencing for viruses in children with rapid-onset type 1 diabetes.

ABSTRACT:

Aims/hypothesis

Viruses are candidate causative agents in the pathogenesis of autoimmune (type 1) diabetes. We hypothesised that children with a rapid onset of type 1 diabetes may have been exposed to such agents shortly before the initiation of islet autoimmunity, possibly at high dose, and thus study of these children could help identify viruses involved in the development of autoimmune diabetes.

Methods

We used next-generation sequencing to search for viruses in plasma samples and examined the history of infection and fever in children enrolled in The Environmental Determinants of Diabetes in the Young (TEDDY) study who progressed to type 1 diabetes within 6 months from the appearance of islet autoimmunity, and in matched islet-autoantibody-negative controls.

Results</

SUBMITTER: Lee HS 

PROVIDER: S-EPMC4019381 | biostudies-literature | 2013 Aug

REPOSITORIES: biostudies-literature