A comparison of statistical methods for detecting context-modulated functional connectivity in fMRI.

ABSTRACT: Many cognitive and clinical neuroscience research studies seek to determine how contextual factors modulate cognitive processes. In fMRI, hypotheses about how context modulates distributed patterns of information processing are often tested by comparing functional connectivity between neural regions A and B as a function of task conditions X and Y, which is termed context-modulated functional connectivity (FC). There exist two exploratory statistical approaches to testing context-modulated FC: the beta-series method and psychophysiological interaction (PPI) analysis methods. While these approaches are commonly used, their relative power for detecting context-modulated FC is unknown, especially with respect to real-world experimental parameters (e.g., number of stimulus repetitions, inter-t

SUBMITTER: Cisler JM 

PROVIDER: S-EPMC4019671 | biostudies-literature | 2014 Jan

REPOSITORIES: biostudies-literature