Transcriptional profiling of the human fibrillin/LTBP gene family, key regulators of mesenchymal cell functions.

ABSTRACT: The fibrillins and latent transforming growth factor binding proteins (LTBPs) form a superfamily of extracellular matrix (ECM) proteins characterized by the presence of a unique domain, the 8-cysteine transforming growth factor beta (TGFβ) binding domain. These proteins are involved in the structure of the extracellular matrix and controlling the bioavailability of TGFβ family members. Genes encoding these proteins show differential expression in mesenchymal cell types which synthesize the extracellular matrix. We have investigated the promoter regions of the seven gene family members using the FANTOM5 CAGE database for human. While the protein and nucleotide sequences show considerable sequence similarity, the promoter regions were quite diverse. Most genes had a single predominant transc

SUBMITTER: Davis MR 

PROVIDER: S-EPMC4019825 | biostudies-literature | 2014 May

REPOSITORIES: biostudies-literature