A high-performance nanobio photocatalyst for targeted brain cancer therapy.
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ABSTRACT:
SUBMITTER: Rozhkova EA
PROVIDER: S-EPMC4019973 | biostudies-literature | 2009 Sep
REPOSITORIES: biostudies-literature
Publications
A high-performance nanobio photocatalyst for targeted brain cancer therapy.
Rozhkova Elena A EA Ulasov Ilya I Lai Barry B Dimitrijevic Nada M NM Lesniak Maciej S MS Rajh Tijana T
Nano letters 20090901 9
We report pronounced and specific antiglioblastoma cell phototoxicity of 5 nm TiO(2) particles covalently tethered to an antibody via a dihydroxybenzene bivalent linker. The linker application enables absorption of a visible part of the solar spectrum by the nanobio hybrid. The phototoxicity is mediated by reactive oxygen species (ROS) that initiate programmed death of the cancer cell. Synchrotron X-ray fluorescence microscopy (XFM) was applied for direct visualization of the nanobioconjugate di ...[more]
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