Sitagliptin added to voglibose monotherapy improves glycemic control in patients with type 2 diabetes.

ABSTRACT:

Aims/introduction

Type 2 diabetes mellitus is a progressive disease that frequently requires patients to use more than one oral antihyperglycemic agent to achieve adequate glycemic control. The present multicenter, randomized study assessed the efficacy and safety of the addition of sitagliptin to ongoing voglibose monotherapy (0.2-0.3 mg three times daily) in Japanese patients with type 2 diabetes mellitus who had inadequate glycemic control (glycated hemoglobin ≥6.9% and <10.5%).

Materials and methods

The present study had an initial 12-week, double-blind treatment period in which patients were randomized (1:1) to sitagliptin 50 mg/day (n = 70) or placebo (n = 63), followed by a 40-week, open-label treatment period during which all patients received sitagliptin 50 mg/day,

SUBMITTER: Tajima N 

PROVIDER: S-EPMC4020255 | biostudies-literature | 2013 Nov

REPOSITORIES: biostudies-literature