Pilot genome-wide study of tandem 3' UTRs in esophageal cancer using high-throughput sequencing.

ABSTRACT: Regulatory regions within the 3' untranslated region (UTR) influence polyadenylation (polyA), translation efficiency, localization and stability of mRNA. Alternative polyA (APA) has been considered to have a key role in gene regulation since 2008. Esophageal carcinoma is the eighth most common type of cancer worldwide. The association between polyA and disease highlights the requirement for comprehensive characterization of genome-wide polyA profiles. In the present study, global polyA profiles were established using the sequencing APA sites (SAPAS) method in order to elucidate the interrelation between 3' UTR length and the development of esophageal cancer. PolyA profiles were analyzed in squamous cell carcinoma, with ~903 genes identified to have shortened 3' UTRs and 917 genes identifie

SUBMITTER: Sun M 

PROVIDER: S-EPMC4020480 | biostudies-literature | 2014 May

REPOSITORIES: biostudies-literature