Quantitative characterization of cellular membrane-receptor heterogeneity through statistical and computational modeling.

ABSTRACT: Cell population heterogeneity can affect cellular response and is a major factor in drug resistance. However, there are few techniques available to represent and explore how heterogeneity is linked to population response. Recent high-throughput genomic, proteomic, and cellomic approaches offer opportunities for profiling heterogeneity on several scales. We have recently examined heterogeneity in vascular endothelial growth factor receptor (VEGFR) membrane localization in endothelial cells. We and others processed the heterogeneous data through ensemble averaging and integrated the data into computational models of anti-angiogenic drug effects in breast cancer. Here we show that additional modeling insight can be gained when cellular heterogeneity is considered. We present comprehensive sta

SUBMITTER: Weddell JC 

PROVIDER: S-EPMC4020774 | biostudies-literature | 2014

REPOSITORIES: biostudies-literature