Spontaneous reversion of the angiogenic phenotype to a nonangiogenic and dormant state in human tumors.

ABSTRACT:

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The angiogenic switch, a rate-limiting step in tumor progression, has already occurred by the time most human tumors are detectable. However, despite significant study of the mechanisms controlling this switch, the kinetics and reversibility of the process have not been explored. The stability of the angiogenic phenotype was examined using an established human liposarcoma xenograft model. Nonangiogenic cells inoculated into immunocompromised mice formed microscopic tumors that remained dormant for approximately 125 days (vs. <40 days for angiogenic cells) whereupon the vast majority (>95%) initiated angiogenic growth with second-order kinetics. These original, clonally derived angiogenic tumor cells were passaged through four in vivo cycles. At each cycle, a new set of s

SUBMITTER: Rogers MS 

PROVIDER: S-EPMC4020951 | biostudies-literature | 2014 May

REPOSITORIES: biostudies-literature