Genetic diversity and antifungal susceptibility profiles in causative agents of sporotrichosis.

ABSTRACT:

Background

Sporotrichosis is a chronic subcutaneous mycosis of humans and animals, which is typically acquired by traumatic inoculation of plant material contaminated with Sporothrix propagules, or via animals, mainly felines. Sporothrix infections notably occur in outbreaks, with large epidemics currently taking place in southeastern Brazil and northeastern China. Pathogenic species include Sporothrix brasiliensis, Sporothrix schenckii s. str., Sporothrix globosa, and Sporothrix luriei, which exhibit differing geographical distribution, virulence, and resistance to antifungals. The phylogenetically remote species Sporothrix mexicana also shows a mild pathogenic potential.

Methods

We assessed a genetically diverse panel of 68 strains. Susceptibility profiles of medically imp

SUBMITTER: Rodrigues AM 

PROVIDER: S-EPMC4021050 | biostudies-literature | 2014 Apr

REPOSITORIES: biostudies-literature