RasG signaling is important for optimal folate chemotaxis in Dictyostelium.

ABSTRACT:

Background

Signaling pathways linking receptor activation to actin reorganization and pseudopod dynamics during chemotaxis are arranged in complex networks. Dictyostelium discoideum has proven to be an excellent model system for studying these networks and a body of evidence has indicated that RasG and RasC, members of the Ras GTPase subfamily function as key chemotaxis regulators. However, recent evidence has been presented indicating that Ras signaling is not important for Dictyostelium chemotaxis. In this study, we have reexamined the role of Ras proteins in folate chemotaxis and then, having re-established the importance of Ras for this process, identified the parts of the RasG protein molecule that are involved.

Results

A direct comparison of folate chemotaxis methodolo

SUBMITTER: Chattwood A 

PROVIDER: S-EPMC4021067 | biostudies-literature | 2014 Apr

REPOSITORIES: biostudies-literature