Cost-effectiveness of family history-based colorectal cancer screening in Australia.

ABSTRACT:

Background

With 14.234 diagnoses and over 4047 deaths reported in 2007, colorectal cancer (CRC) is the second most common cancer and second most common cause of cancer-related mortality in Australia. The direct treatment cost has recently been estimated to be around AU$1.2 billion for the year 2011, which corresponds to a four-fold increase, compared the cost reported in 2001. Excluding CRCs due to known rare genetic disorders, 20% to 25% of all CRCs occur in a familial aggregation setting due to genetic variants or shared environmental risk factors that are yet to be characterised. A targeted screening strategy addressed to this segment of the population is a potentially valuable tool for reducing the overall burden of CRC.

Methods

We developed a Markov model to assess the

SUBMITTER: Ouakrim DA 

PROVIDER: S-EPMC4021190 | biostudies-literature | 2014 Apr

REPOSITORIES: biostudies-literature