Chloroquine efficacy studies confirm drug susceptibility of Plasmodium vivax in Chennai, India.

ABSTRACT:

Background

Assessing the Plasmodium vivax burden in India is complicated by the potential threat of an emerging chloroquine (CQ) resistant parasite population from neighbouring countries in Southeast Asia. Chennai, the capital of Tamil Nadu and an urban setting for P. vivax in southern India, was selected as a sentinel site for investigating CQ efficacy and sensitivity in vivax malaria.

Methods

CQ efficacy was evaluated with a 28-day in vivo therapeutic study, while CQ sensitivity was measured with an in vitro drug susceptibility assay. In both studies, isolates also underwent molecular genotyping to investigate correlations between parasite diversity and drug susceptibility to CQ. Molecular genotyping included sequencing a 604 base pair (bp) fragment of the P. vivax multidr

SUBMITTER: Shalini S 

PROVIDER: S-EPMC4021252 | biostudies-literature | 2014 Mar

REPOSITORIES: biostudies-literature