Opposing microtubule motors control motility, morphology and cargo segregation during ER-to-Golgi transport.

ABSTRACT: We recently demonstrated that dynein and kinesin motors drive multiple aspects of endosomal function in mammalian cells. These functions include driving motility, maintaining morphology (notably through providing longitudinal tension to support vesicle fission), and driving cargo sorting. Microtubule motors drive bidirectional motility during traffic between the endoplasmic reticulum (ER) and Golgi. Here, we have examined the role of microtubule motors in transport carrier motility, morphology, and domain organization during ER-to-Golgi transport. We show that, consistent with our findings for endosomal dynamics, microtubule motor function during ER-to-Golgi transport of secretory cargo is required for motility, morphology, and cargo sorting within vesicular tubular carriers en route to th

SUBMITTER: Brown AK 

PROVIDER: S-EPMC4021352 | biostudies-literature | 2014 Apr

REPOSITORIES: biostudies-literature