Host defence related responses in bovine milk during an experimentally induced Streptococcus uberis infection.

ABSTRACT:

Background

Milk contains a range of proteins of moderate or low abundance that contribute to host defence. Characterisation of these proteins, the extent to which their abundance is regulated by pathogenic stimuli, and the variability of their response between and within individual animals would facilitate a better understanding of the molecular basis for this important function of milk.

Results

We have characterised the host defence proteins in bovine milk and their responses to intra-mammary infection by a common Gram positive mastitis pathogen, Streptococcus uberis, using a combination of 2D gel electrophoresis and GeLC mass spectrometry. In total, 68 host defence-associated proteins were identified, 18 of which have a direct antimicrobial function, 23 of which have a pat

SUBMITTER: Smolenski GA 

PROVIDER: S-EPMC4021463 | biostudies-literature | 2014

REPOSITORIES: biostudies-literature