The selective cytotoxic anti-cancer properties and proteomic analysis of Trigonella Foenum-Graecum.

ABSTRACT:

Background

There are a number of dietary components that may prove useful in the prevention and treatment of cancer. In some cultures, fenugreek seeds are used to treat cancer. The current study focuses on the anticancer properties and proteomic profiles of fenugreek seeds, and is prompted by the clinical profile of a case of primary CNS T cell lymphoma that responded to fenugreek treatment and resulted in tumor regression.

Method

Various normal and cancer cell lines were exposed to fenugreek extract at differing concentrations (100 μg/ml, 200 μg/ml and 300 μg/ml) and at different time points (0, 24, 48, 72 and 96 hrs). Protein fingerprints of fenugreek grain/seed types, obtained from four different geographical regions, were analyzed by proteomic expression profiles.

Res

SUBMITTER: Alsemari A 

PROVIDER: S-EPMC4021494 | biostudies-literature | 2014 Mar

REPOSITORIES: biostudies-literature