The elevated preoperative platelet-to-lymphocyte ratio predicts poor prognosis in breast cancer patients.

ABSTRACT:

Background

The elevation of the platelet-to-lymphocyte ratio (PLR), an easily applicable blood test based on platelet and lymphocyte counts has been associated with poor prognosis in patients with different types of cancer. The present study was aimed to investigate the prognostic significance of the preoperative PLR in a large cohort of breast cancer patients.

Methods

Data from 793 consecutive non-metastatic breast cancer patients, treated between 1999 and 2004, were evaluated retrospectively. The optimal cutoff values for the PLR were calculated using receiver operating curve analysis. Cancer-specific survival (CSS), overall survival (OS) as well as distant metastasis-free survival (DMFS) were assessed using the Kaplan-Meier method. To evaluate the independent prognostic s

SUBMITTER: Krenn-Pilko S 

PROVIDER: S-EPMC4021515 | biostudies-literature | 2014 May

REPOSITORIES: biostudies-literature