Proteomics analysis of melanoma metastases: association between S100A13 expression and chemotherapy resistance.

ABSTRACT:

Background

Disseminated cutaneous malignant melanoma (CMM) is commonly unresponsive to standard chemotherapies, and there are as yet no predictive markers of therapy response.

Methods

In the present study we collected fresh-frozen pretreatment lymph-node metastasis samples (n=14) from melanoma patients with differential response to dacarbazine (DTIC) or temozolomide (TMZ) chemotherapy, to identify proteins with an impact on treatment response. We performed quantitative protein profiling using tandem mass spectrometry and compared the proteome differences between responders (R) and non-responders (NR), matched for age, gender and histopathological type of CMM.

Results

Biological pathway analyses showed several signalling pathways differing between R vs NR, including Rh

SUBMITTER: Azimi A 

PROVIDER: S-EPMC4021518 | biostudies-literature | 2014 May

REPOSITORIES: biostudies-literature