Efficacy and toxicity of external-beam radiation therapy for localised prostate cancer: a network meta-analysis.

ABSTRACT:

Background

Many radiation regimens for treating prostate cancer have been used over the years, but which regimen is optimal for localised or locally advanced prostate cancer lacks consensus. We performed a network meta-analysis to identify the optimal radiation regimen.

Methods

We systematically reviewed data from 27 randomised controlled trials and could group seven radiation regimens as follows: low- and high-dose radiation therapy (LDRT and HDRT), LDRT+ short- or long-term androgen deprivation therapy (LDRT+SADT and LDRT+LADT), HDRT+SADT, hypofractionated radiotherapy (HFRT), and HFRT+SADT. The main outcomes were overall mortality (OM), prostate-specific antigen (PSA) failure, cancer-specific mortality, and adverse events.

Results

For the network meta-analysis of 2

SUBMITTER: Zhu Z 

PROVIDER: S-EPMC4021530 | biostudies-literature | 2014 May

REPOSITORIES: biostudies-literature