Estimating breast cancer mortality reduction and overdiagnosis due to screening for different strategies in the United Kingdom.

ABSTRACT:

Background

The benefits and harms of population-wide mammography screening have been long debated. This study evaluated the impact of screening frequency and age range on breast cancer mortality reduction and overdiagnosis.

Methods

We developed a Markov simulation model for the evaluation of mammography screening in a cohort of British women born in 1935-40.

Results

For triennial screening in women aged 47-73, breast cancer mortality reduction and overdiagnosis was 18.1% (95% confidence interval: 17.3%, 19.0%) and 5.6% (5.1%, 6.1%), of all breast cancer deaths and diagnoses, respectively, from age 40 to 85 years. For annual screening in the same age range, estimates for both outcomes increased considerably to 35.0% (34.2%, 35.7%) and 7.6% (7.1%, 8.1%), respectively. F

SUBMITTER: Gunsoy NB 

PROVIDER: S-EPMC4021535 | biostudies-literature | 2014 May

REPOSITORIES: biostudies-literature