Multipoint targeting of the PI3K/mTOR pathway in mesothelioma.

ABSTRACT:

Background

Mesothelioma is a notoriously chemotherapy-resistant neoplasm, as is evident in the dismal overall survival for patients with those of asbestos-associated disease. We previously demonstrated co-activation of multiple receptor tyrosine kinases (RTKs), including epidermal growth factor receptor (EGFR), MET, and AXL in mesothelioma cell lines, suggesting that these kinases could serve as novel therapeutic targets. Although clinical trials have not shown activity for EGFR inhibitors in mesothelioma, concurrent inhibition of various activated RTKs has pro-apoptotic and anti-proliferative effects in mesothelioma cell lines. Thus, we hypothesised that a coordinated network of multi-RTK activation contributes to mesothelioma tumorigenesis.

Methods

Activation of PI3K/AKT/m

SUBMITTER: Zhou S 

PROVIDER: S-EPMC4021537 | biostudies-literature | 2014 May

REPOSITORIES: biostudies-literature