Exhaled breath profiling for diagnosing acute respiratory distress syndrome.

ABSTRACT:

Background

The acute respiratory distress syndrome (ARDS) is a common, devastating complication of critical illness that is characterized by pulmonary injury and inflammation. The clinical diagnosis may be improved by means of objective biological markers. Electronic nose (eNose) technology can rapidly and non-invasively provide breath prints, which are profiles of volatile metabolites in the exhaled breath. We hypothesized that breath prints could facilitate accurate diagnosis of ARDS in intubated and ventilated intensive care unit (ICU) patients.

Methods

Prospective single-center cohort study with training and temporal external validation cohort. Breath of newly intubated and mechanically ventilated ICU-patients was analyzed using an electronic nose within 24 hours after a

SUBMITTER: Bos LD 

PROVIDER: S-EPMC4021554 | biostudies-literature | 2014 Apr

REPOSITORIES: biostudies-literature