Reprogramming non-human primate somatic cells into functional neuronal cells by defined factors.

ABSTRACT:

Background

The common marmoset (Callithrix jacchus) is a New World primate sharing many similarities with humans. Recently developed technology for generating transgenic marmosets has opened new avenues for faithful recapitulation of human diseases, which could not be achieved in rodent models. However, the longer lifespan of common marmosets compared with rodents may result in an extended period for in vivo analysis of common marmoset disease models. Therefore, establishing rapid and efficient techniques for obtaining neuronal cells from transgenic individuals that enable in vitro analysis of molecular mechanisms underlying diseases are required. Recently, several groups have reported on methods, termed direct reprogramming, to generate neuronal cells by defined factors from somat

SUBMITTER: Zhou Z 

PROVIDER: S-EPMC4021617 | biostudies-literature | 2014 Apr

REPOSITORIES: biostudies-literature