Combined meta-analysis of systemic effects of allogeneic stem cell transplantation and systemic sclerosis.

ABSTRACT:

Background

Chronic graft-versus-host disease (cGVHD) is a major factor of morbidity and mortality for allogeneic stem cell transplantation (aSCT). The skin and internal organ involvement is the most common systemic complication of cGVHD and closely resembles systemic sclerosis (SSc). Circulating lymphocytes characterize the autoimmune nature of both conditions. Therefore we hypothesized that the common clinical manifestation (systemic organ and skin injury) and the common underlying players (lymphocytes) justify the combined meta-analysis of these diseases.

Results

The aSCT and SSc datasets were uploaded from Gene Expression Omnibus (GEO), a public functional genomics data repository. The available microarray studies of peripheral blood mononuclear cells (PBMCs) and isolated

SUBMITTER: Grigoryev DN 

PROVIDER: S-EPMC4021691 | biostudies-literature | 2014 Mar

REPOSITORIES: biostudies-literature