The TMEFF2 tumor suppressor modulates integrin expression, RhoA activation and migration of prostate cancer cells.

ABSTRACT: Cell adhesion and migration play important roles in physiological and pathological states, including embryonic development and cancer invasion and metastasis. The type I transmembrane protein with epidermal growth factor and two follistatin motifs 2 (TMEFF2) is expressed mainly in brain and prostate and its expression is deregulated in prostate cancer. We have previously shown that TMEFF2 can function as a tumor suppressor by inhibiting cell migration and invasion of prostate cells. However, the molecular mechanisms involved in this inhibition are not clear. In this study we demonstrate that TMEFF2 affects cell adhesion and migration of prostate cancer cells and that this effect correlates with changes in integrin expression and RhoA activation. Deletion of a 13 basic-rich amino acid regio

SUBMITTER: Chen X 

PROVIDER: S-EPMC4021708 | biostudies-literature | 2014 Jun

REPOSITORIES: biostudies-literature