Genome-wide association study of circulating vitamin D-binding protein.

ABSTRACT:

Background

Vitamin D status may influence a spectrum of health outcomes, including osteoporosis, arthritis, cardiovascular disease, and cancer. Vitamin D-binding protein (DBP) is the primary carrier of vitamin D in the circulation and regulates the bioavailability of 25-hydroxyvitamin D. Epidemiologic studies have shown direct DBP-risk relations and modification by DBP of vitamin D-disease associations.

Objective

We aimed to characterize common genetic variants that influence the DBP biochemical phenotype.

Design

We conducted a genome-wide association study (GWAS) of 1380 men through linear regression of single-nucleotide polymorphisms (SNPs) in the Illumina HumanHap500/550/610 array on fasting serum DBP, assuming an additive genetic model, with adjustment for age at

SUBMITTER: Moy KA 

PROVIDER: S-EPMC4021784 | biostudies-literature | 2014 Jun

REPOSITORIES: biostudies-literature