LIM homeodomain transcription factor Isl1 directs normal pyloric development by targeting Gata3.

ABSTRACT:

Background

Abnormalities in pyloric development or in contractile function of the pylorus cause reflux of duodenal contents into the stomach and increase the risk of gastric metaplasia and cancer. Abnormalities of the pyloric region are also linked to congenital defects such as the relatively common neonatal hypertrophic pyloric stenosis, and primary duodenogastric reflux. Therefore, understanding pyloric development is of great clinical relevance. Here, we investigated the role of the LIM homeodomain transcription factor Isl1 in pyloric development.

Results

Examination of Isl1 expression in developing mouse stomach by immunohistochemistry, whole mount in situ hybridization and real-time quantitative PCR demonstrated that Isl1 is highly expressed in developing mouse stomach,

SUBMITTER: Li Y 

PROVIDER: S-EPMC4021819 | biostudies-literature | 2014 Mar

REPOSITORIES: biostudies-literature