Ontology highlight
ABSTRACT:
SUBMITTER: Wang XW
PROVIDER: S-EPMC4022066 | biostudies-literature | 2014
REPOSITORIES: biostudies-literature
BioMed research international 20140430
IDH1/2 mutation is the most frequent genomic alteration found in gliomas, affecting 40% of these tumors and is one of the earliest alterations occurring in gliomagenesis. We investigated a series of 1305 gliomas and showed that IDH mutation is almost constant in 1p19q codeleted tumors. We found that the distribution of IDH1(R132H) , IDH1(nonR132H) , and IDH2 mutations differed between astrocytic, mixed, and oligodendroglial tumors, with an overrepresentation of IDH2 mutations in oligodendroglial ...[more]