Association of GRM3 polymorphism with white matter integrity in schizophrenia.

ABSTRACT:

Background

While the functional disconnectivity hypothesis of schizophrenia has received considerable attention, fewer studies have investigated the contribution of genotype to structural connectivity between brain regions either in schizophrenia patients or in healthy controls. In this study, we obtained diffusion tensor imaging (DTI) data and genome-wide single nucleotide polymorphism (SNP) data from 74 cases and 87 age- and gender-matched controls.

Methods

We used independent component analysis (ICA) to analyze fractional anisotropy (FA) values and correlated FA values with 121 SNPs in genes associated with myelination and/or schizophrenia risk.

Results

Using ICA, we identified 6 maximally independent components in which the majority of the voxels corresponded to k

SUBMITTER: Mounce J 

PROVIDER: S-EPMC4022143 | biostudies-literature | 2014 May

REPOSITORIES: biostudies-literature