Implications of bevacizumab discontinuation in adults with recurrent glioblastoma.

ABSTRACT:

Background

Patients with recurrent glioblastoma benefiting from bevacizumab are often treated indefinitely due to concerns regarding rebound tumor recurrence upon discontinuation. However, treatment is discontinued for reasons other than disease progression in a subset of these patients, the characteristics and outcomes of which are poorly defined.

Methods

Of 342 adults with recurrent glioblastoma in our database treated with bevacizumab, 82 received treatment for ≥ 6 months; of these, bevacizumab was discontinued for reasons other than tumor progression in 18 patients (Bev-D) and for disease progression in the remainder (Bev-S). The impact of discontinuation on outcome was assessed with discontinuation as a time-dependent covariate in a Cox hazards model for progression-fre

SUBMITTER: Anderson MD 

PROVIDER: S-EPMC4022226 | biostudies-literature | 2014 Jun

REPOSITORIES: biostudies-literature