Stringent homology-based prediction of H. sapiens-M. tuberculosis H37Rv protein-protein interactions.

ABSTRACT:

Background

H. sapiens-M. tuberculosis H37Rv protein-protein interaction (PPI) data are essential for understanding the infection mechanism of the formidable pathogen M. tuberculosis H37Rv. Computational prediction is an important strategy to fill the gap in experimental H. sapiens-M. tuberculosis H37Rv PPI data. Homology-based prediction is frequently used in predicting both intra-species and inter-species PPIs. However, some limitations are not properly resolved in several published works that predict eukaryote-prokaryote inter-species PPIs using intra-species template PPIs.

Results

We develop a stringent homology-based prediction approach by taking into account (i) differences between eukaryotic and prokaryotic proteins and (ii) differences between inter-species and intra-

SUBMITTER: Zhou H 

PROVIDER: S-EPMC4022245 | biostudies-literature | 2014 Apr

REPOSITORIES: biostudies-literature